Insulin sensitivity is a Rubik’s Cube
نویسندگان
چکیده
منابع مشابه
How muscle insulin sensitivity is regulated: testing of a hypothesis.
Muscle contractions induce an increase in glucose transport. The acute effect of muscle contractions on glucose transport is independent of insulin and reverses rapidly after cessation of exercise. As the acute increase in glucose transport reverses, a marked increase in the sensitivity of muscle to insulin occurs. The mechanism for this phenomenon is unknown. We hypothesize that an increase in...
متن کاملModeled Insulin Sensitivity and Interstitial Insulin Action from a Pilot Study of Dynamic Insulin Sensitivity Tests
An accurate test for insulin resistance can delay or prevent the development of Type 2 diabetes and its complications. The current gold standard test, CLAMP, is too labor intensive to be used in general practice. A recently developed dynamic insulin sensitivity test, DIST, uses a glucose-insulin-C-peptide model to calculate model-based insulin sensitivity, SI . Preliminary results show good cor...
متن کاملDoc2b Is a Key Effector of Insulin Secretion and Skeletal Muscle Insulin Sensitivity
Exocytosis of intracellular vesicles, such as insulin granules, is carried out by soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) and Sec1/Munc18 (SM) proteins. An additional regulatory protein, Doc2b (double C2 domain), has recently been implicated in exocytosis from clonal β-cells and 3T3-L1 adipocytes. Here, we investigated the role of Doc2b in insulin secretion...
متن کاملEndogenous insulin and insulin sensitivity
Results There was a significant inverse correlation between forearm blood flow and insulin sensitivity (r="0·67, P=0·03), patients with lesser degrees of insulin sensitivity having the greater forearm blood flows. There was no correlation with the other haemodynamic or neurohumoral parameters. Patients with greater insulin resistance tended to have higher circulating endogenous insulin levels, ...
متن کاملZataria multiflora increases insulin sensitivity and PPARγ gene expression in high fructose fed insulin resistant rats
Objective(s):In insulin resistance, the insulin action in liver, muscles and adipocytes decreases and result in hyperglycemia, dyslipidemia and hyperinsulinemia. In this study we evaluate the effect of Zataria multiflora extract on insulin sensitivity in high fructose fed insulin resistant rats, since this extract was shown antihyperglycemic effect in streptozotocin induced diabetes in rats. ...
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ژورنال
عنوان ژورنال: The American Journal of Clinical Nutrition
سال: 2016
ISSN: 0002-9165,1938-3207
DOI: 10.3945/ajcn.116.136127